Alnylam Pharmaceuticals develops and commercializes drugs using RNA interference technology to treat genetic and metabolic diseases across multiple therapeutic areas including amyloidosis, liver disease, neurological disorders, and blood disorders. The company markets six approved medications and maintains an extensive pipeline of candidates in various clinical trial stages, from Phase 1 through Phase 3, alongside partnerships with major pharmaceutical firms. Founded in 2002 and based in Cambridge, Massachusetts, the company operates internationally with a focus on rare and severe conditions.
1Y: 165.00 (-63.8%) · range 165.00–473.29
entry readiness 70 · GOOD SETUP · exit proximity 0
Value area 197.23–288.62 · 100% of 120d volume overhead · heavy supply
ALNY is a genuinely divided dossier: strong fundamentals (77) and a large earnings surprise collide with a broken tape (technical 7, Markov DOWN with 89% persistence) and a WEAKENING biotech complex. The daily lane itself resolves this by calling WATCH at 0% size — entry zone but setup unconfirmed — which is the honest read. Until the technical picture turns, the fundamental case has no trigger.
- Fundamentals leg strong and consistent across views: conviction-blend fundamentals 77 and absolute-score fundamental 77
- Earnings Surprise source fired hot at 0.967 and Buildup leg is maxed at 100
- Peer cluster CONFIRM with laggard z +5.1, and readiness at 70 [GOOD SETUP] marks a credible entry zone
- Markov trend DOWN with 89% probability of staying, and absolute-score technical just 7 in a MeanRev regime — the tape is broken
- Daily lane is WATCH at 0% size (setup not confirmed), not OPEN — no actual trigger
- Biotech cluster WEAKENING (rank 5) and a Breakdown Signal (0.120) fired; congress net -1 seller
- Realised prior flag returned -1.4% at both 20d/40d with MFE -1.4% — no follow-through; no Monte Carlo on record
Invalidated if: A daily-lane flip from WATCH to OPEN on a confirmed entry trigger (or the Markov state turning UP) would make this cautious-neutral read wrong; a close that extends the downtrend confirms it.
| Source | Score | Last seen |
|---|---|---|
| earnings-surprise | 0.967 | Oct 30, 2026 |
| breakdown-signal | 0.120 | Oct 30, 2026 |
WEAKENING · rank 5 · none
| Horizon | Return | MFE | State |
|---|---|---|---|
| 20d | -1.43% | -1.43% | 1/20d |
| 40d | -1.43% | -1.43% | 1/40d |